Selected Publications from Celentyx Scientists
T cells/Immune checkpoints
B Cells
Antibody Engineering
Macrophages/Dendritic Cells
NK Cells
Fibroblasts/Fibrosis
Mast Cells/Eosinophils
Neuroscience/Pharmacology
Receptor Trafficking
B Cells
Antibody Engineering
Macrophages/Dendritic Cells
NK Cells
Fibroblasts/Fibrosis
Mast Cells/Eosinophils
Neuroscience/Pharmacology
Receptor Trafficking
T cells/Immune checkpoints
Impact of a varied set of stimuli on a suite of immunological parameters within peripheral blood mononuclear cells: toward a non-animal approach for assessing immune modulation by materials intended for human use.
Cochrane S, Rajagopal R, Sheffield D, Stewart F, Hathaway L, Barnes NM, Qureshi O, Gordon J. Front Toxicol. 2024 Apr 26;6:1335110. doi: 10.3389/ftox.2024.1335110. eCollection 2024.PMID: 38737195
T regulatory cells as a potential therapeutic target in psychosis? Current challenges and future perspectives.
Corsi-Zuelli F, Deakin B, de Lima MHF, Qureshi O, Barnes NM, Upthegrove R, Louzada-Junior P, Del-Ben CM. Brain Behav Immun Health. 2021 Aug 19;17:100330. doi: 10.1016/j.bbih.2021.100330. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0260954
Regulation of CTLA-4 recycling by LRBA and Rab11
Janman D, Hinze C, Kennedy A, Halliday N, Waters E, Williams C, Rowshanravan B, Hou TZ, Minogue S, Qureshi OS, Sansom DM. Immunology. 2021 Sep;164(1):106-119. doi: 10.1111/imm.13343. Epub 2021 Jun 6. PMID: 33960403; PMCID: PMC8358724.
Ex vivo modelling of PD‑1/PD‑L1 immune checkpoint blockade under acute, chronic, and exhaustion‑like conditions of T‑cell stimulations.
Roberts A, Bentley L, Tang T, Stewart F, Pallini C, Juvvanapudi J, Wallace GR, Cooper AJ, Scott A, Thickett D, Lugg ST, Bancroft H, Hemming B, Ferris C, Langman G, Robinson A, Chapman J, Naidu B, Pinkney T, Taylor GS, Brock K, Stamataki Z, Brady CA, Curnow SJ, Gordon J, Qureshi OS & Barnes NM. Sci Rep 11, 4030 (2021). https://doi.org/10.1038/s41598-021-83612-3
Hepatocytes Delete Regulatory T Cells by Enclysis, a CD4+ T Cell Engulfment Process.
Davies SP, Reynolds GM, Wilkinson AL, Li X, Rose R, Leekha M, Liu YS, Gandhi R, Buckroyd E, Grove J, Barnes NM, May RC, Hubscher SG, Adams DH, Huang Y, Qureshi O, Stamataki Z. Cell Rep. 2019 Nov 5;29(6):1610-1620.e4. doi: 10.1016/j.celrep.2019.09.068. PMID: 31693899; PMCID: PMC7057271.
Measuring CTLA-4-Dependent Suppressive Function in Regulatory T Cells. Hou TZ, Qureshi OS, Sansom DM. Methods Mol Biol. 2019;1899:87-101. doi: 10.1007/978-1-4939-8938-6_7. PMID: 30649767.
Cytokine production and antigen recognition by human mucosal homing conjunctival effector memory CD8+ T cells.
Williams GP, Pachnio A, Long HM, Rauz S, Curnow SJ. Invest Ophthalmol Vis Sci. 2014 Nov 13;55(12):8523-30. doi: 10.1167/iovs.14-15133. http://iovs.arvojournals.org/article.aspx?articleid=2212722
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4.
Qureshi OS, Zheng Y, Nakamura K, Attridge K, Manzotti C, Schmidt EM, Baker J, Jeffery LE, Kaur S, Briggs Z, Hou TZ, Futter CE, Anderson G, Walker LS, Sansom DM.Science. 2011 Apr 29;332(6029):600-3. doi: 10.1126/science.1202947. Epub 2011 Apr 7. http://science.sciencemag.org/content/332/6029/600.long
A transendocytosis model of CTLA-4 function predicts its suppressive behavior on regulatory T cells.
Hou TZ, Qureshi OS, Wang CJ, Baker J, Young SP, Walker LS, Sansom DM. J Immunol. 2015 Mar 1;194(5):2148-59. doi: 10.4049/jimmunol.1401876. Epub 2015 Jan 28. http://www.jimmunol.org/content/194/5/2148.long
CCR6+ Th cells in the cerebrospinal fluid of persons with multiple sclerosis are dominated by pathogenic non-classic Th1 cells and GM-CSF-only-secreting Th cells.
Restorick SM, Durant L, Kalra S, Hassan-Smith G, Rathbone E, Douglas MR, Curnow SJ. Brain Behav Immun. 2017 Aug;64:71-79. doi: 10.1016/j.bbi.2017.03.008. Epub 2017 Mar 20. https://doi.org/10.1016/j.bbi.2017.03.008
Inhibition of T cell apoptosis in the aqueous humor of patients with uveitis by IL-6/soluble IL-6 receptor trans-signaling. Curnow SJ, Scheel-Toellner D, Jenkinson W, Raza K, Durrani OM, Faint JM, Rauz S, Wloka K, Pilling D, Rose-John S, Buckley CD, Murray PI, Salmon M. (2004) J. Immunol 173:5290-5297. www.jimmunol.org/content/jimmunol/173/8/5290.full.pdf
B Cells
Impact of a varied set of stimuli on a suite of immunological parameters within peripheral blood mononuclear cells: toward a non-animal approach for assessing immune modulation by materials intended for human use.
Cochrane S, Rajagopal R, Sheffield D, Stewart F, Hathaway L, Barnes NM, Qureshi O, Gordon J. Front Toxicol. 2024 Apr 26;6:1335110. doi: 10.3389/ftox.2024.1335110. eCollection 2024.PMID: 38737195
Selective serotonin reuptake inhibitors directly signal for apoptosis in biopsy-like Burkitt lymphoma cells.
Serafeim A, Holder MJ, Grafton G, Chamba A, Drayson MT, Luong QT, Bunce CM, Gregory CD, Barnes NM, Gordon J.(2003) Blood 101:3212-3219. www.bloodjournal.org/content/101/8/3212/tab-figures-only?sso-checked=true
Tone sets the signaling pathways and transcriptome generated in model CD40-pluricompetent L3055 Burkitt's lymphoma cells.
Stewart R, Wei W, Challa A, Armitage RJ, Arrand JR, Rowe M, Young LS, Eliopoulos A and Gordon J.(2007) Journal of Immunology 179:2705-2712 pdfs.semanticscholar.org/64c1/4b9799799e57b9fd33f7ee640f3b9f6b7843.pdf
High sensitivity and specificity of elevated cerebrospinal fluid kappa free light chains in suspected multiple sclerosis.
Hassan-Smith G, Durant L, Tsentemeidou A, Assi LK, Faint JM, Kalra S, Douglas MR, Curnow SJ. J Neuroimmunol. 2014 Nov 15;276(1-2):175-9. doi: 10.1016/j.jneuroim.2014.08.003. Epub 2014 Aug 8. https://doi.org/10.1016/j.jneuroim.2014.08.003
Novel vitamin D analogues; cytotoxic and anti-proliferative activity against a diffuse large B-cell lymphoma cell line and B-cells from healthy donors.
Kozielewicz P, Grafton G, Kutner A, Curnow SJ, Gordon J, Barnes NM. (2016) J Steroid Biochem Mol Biol. 164:98–105 http://europepmc.org/abstract/med/26485664 europepmc.org/abstract/med/26485664
Antibody Engineering
Impact of a varied set of stimuli on a suite of immunological parameters within peripheral blood mononuclear cells: toward a non-animal approach for assessing immune modulation by materials intended for human use.
Cochrane S, Rajagopal R, Sheffield D, Stewart F, Hathaway L, Barnes NM, Qureshi O, Gordon J. Front Toxicol. 2024 Apr 26;6:1335110. doi: 10.3389/ftox.2024.1335110. eCollection 2024.PMID: 38737195
Fc-engineered antibodies with immune effector functions completely abolished.
Wilkinson I, Anderson S, Fry J, Julien LA, Neville D, Qureshi O, Watts G, Hale G. PLoS One. 2021 Dec 21;16(12):e0260954. doi: 10.1371/journal.pone.0260954. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0260954
Multivalent Fcγ-receptor engagement by a hexameric Fc-fusion protein triggers Fcγ-receptor internalisation and modulation of Fcγ-receptor functions.
Qureshi OS, Rowley TF, Junker F, Peters SJ, Crilly S, Compson J, Eddleston A, Björkelund H, Greenslade K, Parkinson M, Davies NL, Griffin R, Pither TL, Cain K, Christodoulou L, Staelens L, Ward E, Tibbitts J, Kiessling A, Smith B, Brennan FR, Malmqvist M, Fallah-Arani F, Humphreys DP. Sci Rep. 2017 Dec 6;7(1):17049. doi: 10.1038/s41598-017-17255-8. https://www.nature.com/articles/s41598-017-17255-8
Macrophages/Dendritic Cells
Interactions of the anti-FcRn monoclonal antibody, rozanolixizumab, with Fcγ receptors and functional impact on immune cells in vitro.
Qureshi OS, Sutton EJ, Bithell RF, West SM, Cutler RM, McCluskey G, Craggs G, Maroof A, Barnes NM, Humphreys DP, Rapecki S, Smith BJ, Shock A. MAbs. 2024 Jan-Dec;16(1):2300155. doi: 10.1080/19420862.2023.2300155. Epub 2024 Jan 19.PMID: 38241085
Aqueous humor suppression of dendritic cell function helps maintain immune regulation in the eye during human uveitis.
Denniston AK, Tomlins P, Williams GP, Kottoor S, Khan I, Oswal K, Salmon M, Wallace GR, Rauz S, Murray PI, Curnow SJ. Invest Ophthalmol Vis Sci. 2012 Feb 21;53(2):888-96. doi: 10.1167/iovs.11-8802. Print 2012 Feb. http://iovs.arvojournals.org/article.aspx?articleid=2188371
Regulation of P2X4 receptors by lysosomal targeting, glycan protection and exocytosis.
Qureshi OS, Paramasivam A, Yu JC, Murrell-Lagnado RD. J Cell Sci. 2007 Nov 1;120(Pt 21):3838-49. Epub 2007 Oct 16. http://jcs.biologists.org/content/120/21/3838
ATP-induced autophagy is associated with rapid killing of intracellular mycobacteria within human monocytes/macrophages.
Biswas D, Qureshi OS, Lee WY, Croudace JE, Mura M, Lammas DA. BMC Immunol. 2008 Jul 15;9:35. doi: 10.1186/1471-2172-9-35. https://bmcimmunol.biomedcentral.com/articles/10.1186/1471-2172-9-35
NK Cells
Inosine Acedoben Dimepranol promotes an early and sustained increase in the natural killer cell component of circulating lymphocytes: A clinical trial supporting anti-viral indications.
Ahmed SR, Newman AS, O'Daly J, Duffy S, Grafton G, Brady CA, Curnow SJ, Barnes NM, Gordon J. (2017) Int. Immunopharmacol. 42:108–114. https://doi.org/10.1016/j.intimp.2016.11.023
Fibroblasts/Fibrosis
Structuring of gellan hydrogel enables the production of inherently antifibrotic, lubricating eye drops.
Moxon SR, Vincent RC, Taylor A, Cassidy B, Moakes RJA, Butt GF, Wallace GR, Metcalfe AD, Williams RL, Barnes NM, Logan A, Rauz S, Grover LM.Acta Biomater. 2025 Oct 1;205:260-269. doi: 10.1016/j.actbio.2025.08.039. Epub 2025 Aug 22.PMID: 40850624
ILB® resolves inflammatory scarring and promotes functional tissue repair.
Hill LJ, Botfield HF, Begum G, Qureshi O, Vigneswara V, Masood I, Barnes NM, Bruce L, Logan A. NPJ Regen Med. 2021 Jan 7;6(1):3. doi: 10.1038/s41536-020-00110-2. https://www.nature.com/articles/s41536-020-00110-2
An immunofluorescence assay for extracellular matrix components highlights the role of epithelial cells in producing a stable, fibrillar extracellular matrix.
Qureshi OS, Bon H, Twomey B, Holdsworth G, Ford K, Bergin M, Huang L, Muzylak M, Healy LJ, Hurdowar V, Johnson TS. Biol Open. 2017 Oct 15;6(10):1423-1433. doi: 10.1242/bio.025866. http://bio.biologists.org/content/6/10/1423 bio.biologists.org/content/6/10/1423
Quantitative and organisational changes in mature extracellular matrix revealed through high-content imaging of total protein fluorescently stained in situ.
Holdsworth G, Bon H, Bergin M, Qureshi O, Paveley R, Atkinson J, Huang L, Tewari R, Twomey B, Johnson T. Sci Rep. 2017 Aug 30;7(1):9963. doi: 10.1038/s41598-017-10298-x. https://www.nature.com/articles/s41598-017-10298-x. www.nature.com/articles/s41598-017-10298-
Mast Cells/Eosinophils
Human lung mast cells modulate the functions of airway smooth muscle cells in asthma.
Alkhouri H, Hollins F, Moir LM, Brightling CE, Armour CL, Hughes JM. Allergy. 2011 Sep;66(9):1231-41. doi: 10.1111/j.1398-9995.2011.02616.x. Epub 2011 May 10. https://doi.org/10.1111/j.1398-9995.2011.02616.x
Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6.
Hollins F, Kaur D, Yang W, Cruse G, Saunders R, Sutcliffe A, Berger P, Ito A, Brightling CE, Bradding P. J Immunol. 2008 Aug 15;181(4):2772-80 www.jimmunol.org/content/181/4/2772.long
Mast cells express IL-13R alpha 1: IL-13 promotes human lung mast cell proliferation and Fc epsilon RI expression.
Kaur D, Hollins F, Woodman L, Yang W, Monk P, May R, Bradding P, Brightling CE. Allergy. 2006 Sep;61(9):1047-53. onlinelibrary.wiley.com/doi/abs/10.1111/j.1398-9995.2006.01139.x
Neuroscience/Pharmacology
P2X7R-mediated IL-1β release by human brain tissue: the impact of CNS-penetrant potential therapeutics.
Cowley J, Harrison N, Pegg A, Chan H, Li Z, Kaur A, Welsh E, Brewin A, Carlos Yam-Puc J, Fensome G, Broome E, Morano IM, Jinks E, Grafton G, Cooper AJ, Ahmed Z, Stevens AR, Anderson FG, Wykes V, Chelvarajah R, Tsermoulas G, Ughratdar I, Zisakis A, O'Halloran PJ, Davies DJ, Land T, Chowdhury YA, Sher Z, Yakoub KM, Bergin C, Galloway L, Upthegrove R, Brady CA, Gordon J, Qureshi O, Belli A, Barnes NM. Brain. 2026 Feb 19:awag068. doi: 10.1093/brain/awag068. Online ahead of print.PMID: 41712436
The Concise Guide to PHARMACOLOGY 2025/26: G protein-coupled receptors.
Alexander SPH, Davenport AP, Kelly E, Gibb AJ, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA, Abbracchio MP, Abraham GR, Agoulnik A, Alexander W, Al-Hosaini K, Bäck M, Baker JG, Barnes NM, Bathgate R, Beaulieu JM, Beck-Sickinger AG, Behrens M, Bennett KA, Bernstein KE, Bettler B, Birdsall NJM, Blaho VA, Bonaventure P, Boulay F, Bousquet C, Bräuner-Osborne H, Brown AJ, Burnstock G, Busnelli M, Caló G, Caruso V, Castaño JP, Catt KJ, Ceruti S, Chazot P, Chiang N, Chini B, Christopoulos A, Chun J, Cianciulli A, Civelli O, Clapp LH, Couture R, Cox HM, Csaba Z, Dahlgren C, Dautzenberg FM, Dent G, Douglas SD, Dournaud P, Dubocovich ML, Eguchi S, Escher E, Filardo EJ, Fong T, Forsman HF, Fumagalli M, Gainetdinov RR, Garelja ML, de Gasparo M, Gbahou F, Gerard C, Gershengorn M, Glass M, Gloriam DE, Gobeil F, Goodfriend TL, Goudet C, Grätz L, Gregory KJ, Gruber C, Gundlach AL, Hamann J, Hanson J, Hartman DS, Hauger RL, Hay DL, Heinemann A, Heitman L, Herr DR, Hollenberg MD, Holliday ND, Holst B, Horiuchi M, Hoyer D, Hunyady L, Husain A, IJzerman AP, Inagami T, Insel PA, Jacobson KA, Jacobson LH, Jensen RT, Jockers R, Jonnalagadda D, Karnik S...
Br J Pharmacol. 2025 Dec;182 Suppl 1:S24-S151. doi: 10.1111/bph.70230.PMID: 41461581
Multivariate Brain-Blood Signatures in Early-Stage Depression and Psychosis.
Popovic D, Weyer C, Dwyer DB, Griffiths SL, Lalousis PA, Barnes NM, Vetter C, Neuner LM, Buciuman MO, Sarisik E, Paolini M, Lichtenstein T, Kambeitz-Ilankovic L, Kambeitz J, Ruhrmann S, Chisholm K, Schultze-Lutter F, Falkai P, Schiltz K, Steiner J, Ziller M, Pergola G, Blasi G, Bertolino A, Romer G, Lencer R, Dannlowski U, Salokangas RKR, Pantelis C, Brambilla P, Borgwardt S, Wood SJ, Meisenzahl E, Koutsouleris N, Upthegrove R; PRONIA Consortium. JAMA Psychiatry. 2026 Feb 1;83(2):172-184. doi: 10.1001/jamapsychiatry.2025.3803.PMID: 41405910
Are we hallucinating or can psychedelic drugs modulate the immune system to control inflammation?
Qureshi O, Cowley J, Pegg A, Cooper AJ, Gordon J, Brady CA, Belli A, Butterworth S, Upthegrove R, Andrews N, Barnes NM. Br J Pharmacol. 2025 Jul 28. doi: 10.1111/bph.70138. Online ahead of print.PMID: 40726049
Current Position and Future Direction of Inflammation in Neuropsychiatric Disorders: A Review.
Upthegrove R, Corsi-Zuelli F, Couch ACM, Barnes NM, Vernon AC.J AMA Psychiatry. 2025 Oct 1;82(10):1030-1046. doi: 10.1001/jamapsychiatry.2025.1369.PMID: 40632530
Depressive and Negative Symptoms in the Early and Established Stages of Schizophrenia: Integrating Structural Brain Alterations, Cognitive Performance, and Plasma Interleukin 6 Levels.
Corsi-Zuelli F, Donohoe G, Griffiths SL, Del-Ben CM, Watson AJ, Burke T, Lalousis PA, McKernan D, Morris D, Kelly J, McDonald C, Patlola SR, Pariante C, Barnes NM, Khandaker GM, Suckling J, Deakin B, Upthegrove R, Dauvermann MR. Biol Psychiatry Glob Open Sci. 2024 Dec 2;5(2):100429. doi: 10.1016/j.bpsgos.2024.100429. eCollection 2025 Mar.PMID: 39911538
Anhedonia as a Potential Transdiagnostic Phenotype With Immune-Related Changes in Recent-Onset Mental Health Disorders.
Lalousis PA, Malaviya A, Khatibi A, Saberi M, Kambeitz-Ilankovic L, Haas SS, Wood SJ, Barnes NM, Rogers J, Chisholm K, Bertolino A, Borgwardt S, Brambilla P, Kambeitz J, Lencer R, Pantelis C, Ruhrmann S, Salokangas RKR, Schultze-Lutter F, Schmidt A, Meisenzahl E, Dwyer D, Koutsouleris N, Upthegrove R, Griffiths SL; PRONIA Consortium. Biol Psychiatry. 2024 Oct 1;96(7):615-622. doi: 10.1016/j.biopsych.2024.05.019. Epub 2024 May 30.PMID: 38823495
Relaxation of mitochondrial hyperfusion in the diabetic retina via N6-furfuryladenosine confers neuroprotection regardless of glycaemic status.
Anderson A, Alfahad N, Wimalachandra D, Bouzinab K, Rudzinska P, Wood H, Fazey I, Xu H, Lyons TJ, Barnes NM, Narendran P, Lord JM, Rauz S, Ganley IG, Curtis TM, Wallace GR, Hombrebueno JR. Nat Commun. 2024 Feb 6;15(1):1124. doi: 10.1038/s41467-024-45387-9.PMID: 38321058
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors.
Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA, Abbracchio MP, Abraham G, Agoulnik A, Alexander W, Al-Hosaini K, Bäck M, Baker JG, Barnes NM, Bathgate R, Beaulieu JM, Beck-Sickinger AG, Behrens M, Bernstein KE, Bettler B, Birdsall NJM, Blaho V, Boulay F, Bousquet C, Bräuner-Osborne H, Burnstock G, Caló G, Castaño JP, Catt KJ, Ceruti S, Chazot P, Chiang N, Chini B, Chun J, Cianciulli A, Civelli O, Clapp LH, Couture R, Cox HM, Csaba Z, Dahlgren C, Dent G, Douglas SD, Dournaud P, Eguchi S, Escher E, Filardo EJ, Fong T, Fumagalli M, Gainetdinov RR, Garelja ML, de Gasparo M, Gerard C, Gershengorn M, Gobeil F, Goodfriend TL, Goudet C, Grätz L, Gregory KJ, Gundlach AL, Hamann J, Hanson J, Hauger RL, Hay DL, Heinemann A, Herr D, Hollenberg MD, Holliday ND, Horiuchi M, Hoyer D, Hunyady L, Husain A, IJzerman AP, Inagami T, Jacobson KA, Jensen RT, Jockers R, Jonnalagadda D, Karnik S, Kaupmann K, Kemp J, Kennedy C, Kihara Y, Kitazawa T, Kozielewicz P, Kreienkamp HJ, Kukkonen JP, Langenhan T, Larhammar D, Leach K, Lecca D, Lee JD, Leeman SE, Leprince J, Li XX, Lolait SJ, Lupp A, Macrae R, Maguire J, … Br J Pharmacol. 2023 Oct;180 Suppl 2:S23-S144. doi: 10.1111/bph.16177.PMID: 38123151
Antidepressants for the prevention of depression following first-episode psychosis (ADEPP): study protocol for a multi-centre, double-blind, randomised controlled trial.
Palmer ER, Griffiths SL, Watkins B, Weetman T, Ottridge R, Patel S, Woolley R, Tearne S, Au P, Taylor E, Sadiq Z, Al-Janabi H, Major B, Marriott C, Husain N, Katshu MZUH, Giacco D, Barnes NM, Walters JTR, Barnes TRE, Birchwood M, Drake R, Upthegrove R.Trials. 2023 Oct 6;24(1):646. doi: 10.1186/s13063-023-07499-3.PMID: 37803384
Network analysis of inflammation and symptoms in recent onset schizophrenia and the influence of minocycline during a clinical trial.
Herniman SE, Wood SJ, Khandaker G, Dazzan P, Pariante CM, Barnes NM, Krynicki CR, Nikkheslat N, Vincent RC, Roberts A, Giordano A, Watson A, Suckling J, Barnes TRE, Husain N, Jones PB, Joyce E, Lawrie SM, Lewis S, Deakin B, Upthegrove R; BeneMin Study Team.Transl Psychiatry. 2023 Sep 18;13(1):297. doi: 10.1038/s41398-023-02570-8.PMID: 37723153
Inflammatory subgroups of schizophrenia and their association with brain structure: A semi-supervised machine learning examination of heterogeneity.
Alexandros Lalousis P, Schmaal L, Wood SJ, L E P Reniers R, Cropley VL, Watson A, Pantelis C, Suckling J, Barnes NM, Pariante C, Jones PB, Joyce E, Barnes TRE, Lawrie SM, Husain N, Dazzan P, Deakin B, Shannon Weickert C, Upthegrove R.Brain Behav Immun. 2023 Oct;113:166-175. doi: 10.1016/j.bbi.2023.06.023. Epub 2023 Jul 7.PMID: 37423513
Protocol for the Psychosis Immune Mechanism Stratified Medicine (PIMS) trial: a randomised double-blind placebo-controlled trial of single-dose tocilizumab in patients with psychosis.
Foley ÉM, Griffiths SL, Murray A, Rogers J, Corsi-Zuelli F, Hickinbotham H, Warwick E, Wilson M, Kaser M, Murray GK, Deakin B, Jadon D, Suckling J, Barnes NM, Upthegrove R, Khandaker GM; PIMS Collaboration. BMJ Open. 2023 Mar 24;13(3):e067944. doi: 10.1136/bmjopen-2022-067944.PMID: 36963796
Inflammation and Brain Structure in Schizophrenia and Other Neuropsychiatric Disorders: A Mendelian Randomization Study.
Williams JA, Burgess S, Suckling J, Lalousis PA, Batool F, Griffiths SL, Palmer E, Karwath A, Barsky A, Gkoutos GV, Wood S, Barnes NM, David AS, Donohoe G, Neill JC, Deakin B, Khandaker GM, Upthegrove R; PIMS Collaboration. JAMA Psychiatry. 2022 May 1;79(5):498-507. doi: 10.1001/jamapsychiatry.2022.0407. https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2790722
International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function.
Barnes NM et al. Pharmacol Rev. 2021 Jan;73(1):310-520. doi: 10.1124/pr.118.015552. https://pharmrev.aspetjournals.org/content/73/1/310.long
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors.
Alexander SP, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Abbracchio MP, Alexander W, Al-Hosaini K, Bäck M, Barnes NM et al. Br J Pharmacol. 2021 Oct;178 Suppl 1:S27-S156. doi: 10.1111/bph.15538. https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15538
Design, synthesis and evaluation of tryptophan analogues as tool compounds to study IDO1 activity.
Cundy NJ, Hare RK, Tang T, Leach AG, Jowitt TA, Qureshi O, Gordon J, Barnes NM, Brady CA, Raven EL, Grainger RS, Butterworth S. RSC Chem Biol. 2021 Sep 13;2(6):1651-1660. doi: 10.1039/d0cb00209g. https://pubs.rsc.org/en/content/articlelanding/2021/CB/D0CB00209G
Novel mechanism of modulation at a ligand-gated ion channel; action of Cl-indole at the 5-HT3A receptor.
Powell AD, Grafton G, Roberts A, Larkin S, O’Neill N, Palandri J, Barnes NM. Br J Pharmacol 173, 3467-3479, 2016. bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.13638
Antioxidant, cytotoxic and anti-proliferative activities and total polyphenol contents of the extracts of Geissospermum reticulate bark.
Sajkowska-Kozielewicz J, Kozielewicz P, Barnes NM, Wawer I, Paradowska K. . Oxid Med Cell Longev doi: 10.1155/2016/2573580. www.hindawi.com/journals/omcl/2016/2573580/
The discovery of diazepinone-based 5-HT3receptor partial agonists.
Manning DD, Guo C, Zhang Z, Ryan KN, Naginskaya J, Choo SH, Masih L, Earley WG, Wierschke JD, Newman AS, Brady CA, Barnes, NM, Guzzo PR. Biorg Med Chem Lett 24, 2578-2581, 2014. www.sciencedirect.com/journal/bioorganic-and-medicinal-chemistry-letters/vol/24/issue/11
Cytokine function in medication-naïve first episode psychosis: a systematic review and meta-analysis.
Upthegrove R, Manzanares-Teson N, Barnes NM. Schizophrenia Res 155, 101-108, 2014 www.sciencedirect.com/science/article/pii/S0920996414001133
The immune system and schizophrenia: an update for clinicians.
Upthegrove, R, Barnes NM Adv Psych Treat 20, 83-91, 2014. pdfs.semanticscholar.org/3813/eb564ccf6a83644a740e4e2e2cb38fec0c3a.pdf
Detection of mRNA encoding receptors by in situ and northern hybridization.
Princivalle AP, Parker RM, Dover TJ, Barnes NM. Methods Mol Biol 897, 261-302, 2012.
Novel serotonin type 3 receptor partial agonists for the potential treatment of irritable bowel syndrome.
Manning DD, Cioffi CL, Usyatinsky A, Fitzpatrick K, Masih L, Guo C, Zhang Z, Choo SH, Sikkander MI, Ryan KN., Naginskaya J, Hassler C, Dobritsa S, Wierschke JD, Earley WG, Butler AS, Brady CA, Barnes NM, Cohen ML, Guzzo PR.
Bioorg Med Chem Lett. 21, 58-61, 2011. www.sciencedirect.com/science/article/pii/S0960894X10017051
The identification of N-glycosylation residues of the human 5-HT3B receptor subunit: importance for cell membrane expression.
Massoura AN, Dover TJ, Barnes NM. J. Neurochem. 116, 975-983, 2011. onlinelibrary.wiley.com/doi/abs/10.1111/j.1471-4159.2010.07129.x
Importance of the C-terminus of the human 5-HT3A receptor subunit.
Butler AS, Lindesay SA, Dover TJ, Kennedy MD, Patchell VB, Levine BA, Hope AG, Barnes NM. Neuropharmacology 56, 292-302, 2009. www.sciencedirect.com/science/article/pii/S0028390808003675?via%3Dihub
The 5-HT3 receptor – the relationship between structure and function.
Barnes NM, Hales TG, Lummis SC, Peters JA. Neuropharmacology 56, 273-284, 2009. www.sciencedirect.com/science/article/pii/S0028390808003407?via%3Dihub
Receptor Trafficking
Constitutive clathrin-mediated endocytosis of CTLA-4 persists during T cell activation.
Qureshi OS, Kaur S, Hou TZ, Jeffery LE, Poulter NS, Briggs Z, Kenefeck R, Willox AK, Royle SJ, Rappoport JZ, Sansom DM. J Biol Chem. 2012 Mar 16;287(12):9429-40. doi: 10.1074/jbc.M111.304329. Epub 2012 Jan 19. www.jbc.org/content/287/12/9429.long
Non-canonical YXXGPhi endocytic motifs: recognition by AP2 and preferential utilization in P2X4 receptors.
Royle SJ, Qureshi OS, Bobanović LK, Evans PR, Owen DJ, Murrell-Lagnado RD.J Cell Sci. 2005 Jul 15;118(Pt 14):3073-80. Epub 2005 Jun 28. jcs.biologists.org/content/118/14/3073.long