Celentyx Ltd | Immunology CRO
  • Home
  • Immunology Assays
    • B Cells
    • Haemolysis Testing
    • Human microglia
    • Macrophages/Monocytes
    • Neutrophils/Granulocytes
    • Phagocytosis Assays
    • Regulatory T cells
    • Spheroid Killing Assays
    • Suppression Assays
    • T Cells Activation Assays
    • T Cell Exhaustion Assays
    • TIL and dissociated tumour cell assays
    • Tumour Cell Killing
  • Therapeutic Area
    • Autoimmunity & Inflammation
    • COVID-19
    • Fibrosis
    • Immuno-oncology
    • Neuroinflammation
  • Services
    • Assays on Patient Cells
    • Bespoke Services & Assay Development
    • CyTOF
    • ELISA
    • ELISpot
    • ELLA
    • Flow Cytometry
    • Imaging: High-content
    • Luminex
    • Phosphoflow
    • Seahorse Metabolic Assays
  • About
    • People
    • Publications
    • News
    • Careers
  • Contact

Neutrophils & Granulocytes

Home > Immunology Assays >  Neutrophils/Granulocytes

Assays for measuring neutrophil activation, migration, ROS generation and survival

Granulocytes (polymorphonuclear leukocytes) are a major component of the innate immune system, accounting for the majority of white blood cells. They are phagocytes that protect against bacteria, viruses and other various parasites. This action comes partly from their possession of cytoplasmic granules to aid digestion of the foreign cells. An increase in granulocytes occurs in response to infections, blood cell malignancies (such as leukaemia), and some autoimmune diseases.

Within the population of granulocytes, neutrophils are by far the most prevalent and contribute to the pathogenesis of diseases like inflammatory arthritis, chronic obstructive pulmonary disease (COPD) and Behçet’s disease. Neutropenia leads to susceptibility to infectious with severe cases often life-threatening.

Other granulocytes, eosinophils and basophils are considerably less prevalent compared to neutrophils, but are important to fight infection by, for example, multi-cellular parasites (e.g. worms). Both cell types are also involved in allergic reactions. 

Celentyx use a range of assays to investigate granulocyte function performed on cells freshly isolated from human blood including: activation marker expression, ROS generation, survival, migration.

Assays may be suitable for evaluating modulators of chemokine receptors, DAMP receptors, G-CSFR, GM-CSFR, LFA1, MAC1, PI3k, PKC, Syk, TLRs and others.
Further Immunology Assays
B Cells
Haemolysis Testing
​Human Microglia
​Macrophages/Monocytes
​Phagocytosis Assays
Regulatory T cells​
Spheroid Killing Assay​s
Suppression Assays​​​​​
​T Cell Activation Assays
​
​T Cell Exhaustion Assays
Tumour infiltrating lymphocyte (TIL) and dissociated tumour cell assays​
Tumour Cell Killing Assays


EXAMPLE DATA: 
Right: Ability of a test immunomodulator to promote human neutrophil effector function relative to the maximal effect of a high efficacy positive control. Neutrophil effector function was assessed by flow
cytometry for reactive oxygen species (ROS) activity. The test immunomodulator produced a small but consistent increase in neutrophil effector function.

Neutrophil effector function - ROS generation

Neutrophil Migration
Neutrophil migration

FIND US

Celentyx Ltd
Birmingham Research Park
97 Vincent Drive
Birmingham
B15 2SQ
United Kingdom
Celentyx Innovation Lab
BioEscalator Innovation Building
Roosevelt Drive
Oxford
​OX3 7FZ
United Kingdom

    CONTACT US

Submit
Web Hosting by Bluehost
  • Home
  • Immunology Assays
    • B Cells
    • Haemolysis Testing
    • Human microglia
    • Macrophages/Monocytes
    • Neutrophils/Granulocytes
    • Phagocytosis Assays
    • Regulatory T cells
    • Spheroid Killing Assays
    • Suppression Assays
    • T Cells Activation Assays
    • T Cell Exhaustion Assays
    • TIL and dissociated tumour cell assays
    • Tumour Cell Killing
  • Therapeutic Area
    • Autoimmunity & Inflammation
    • COVID-19
    • Fibrosis
    • Immuno-oncology
    • Neuroinflammation
  • Services
    • Assays on Patient Cells
    • Bespoke Services & Assay Development
    • CyTOF
    • ELISA
    • ELISpot
    • ELLA
    • Flow Cytometry
    • Imaging: High-content
    • Luminex
    • Phosphoflow
    • Seahorse Metabolic Assays
  • About
    • People
    • Publications
    • News
    • Careers
  • Contact