Home > Immunology Assays > B Cells
Assays for measuring B cell activation, immunoglobulin (Ig) production, proliferation and signalling B cells play key roles in the human immune system by producing antibodies and performing a range of other functions such as antigen presentation and cytokine production. They are therefore important therapeutic targets in autoimmune and inflammatory diseases where they may contribute or even initiate disease through the production of pathogenic antibodies. In infectious disease and more recently in immuno-oncology, boosting B cell responses may be of clinical benefit.
Celentyx CSO Professor John Gordon, an ISI Highly Cited Researcher renowned for his work on normal and pathological B cells, has been instrumental in: (i) pioneering studies on human interleukin-4; (ii) establishing the CD23/FCER2 field and; (iii) not simply defining the role of CD40 in B cell physiology but actually originating its nomenclature. John plays a central role in delivering Celentyx’s B cell assay services to study compound impact on key B cell functions and also designs bespoke systems to interrogate more novel B cell roles in immune regulation. Assays may be suitable for evaluating modulators of BAFF, Btk, CD19, CD20, CD22, CD23, CD40, JAK1, JAK2, Syk and others. |
Further Immunology Assays
B Cells Haemolysis Testing Human Microglia Macrophages/Monocytes Neutrophils/Granulocytes Phagocytosis Assays Regulatory T cells Spheroid Killing Assays Suppression Assays T Cell Activation Assays T Cell Exhaustion Assays Tumour infiltrating lymphocyte (TIL) and dissociated tumour cell assays Tumour Cell Killing Assays |
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