Home > Immunology Assays > Antigen-specific Assays
Assays for antigen-specific T cell responsesCelentyx can run plate-based assays for investigating antigen-specific T cell responses (including on purified T cell subsets), quantifying activation markers and proliferation by flow cytometry, or cytokine release by flow cytometry, ELISA, ELISPOT or Luminex, using human primary cells either from healthy volunteers or patients with underlying disease. The example below shows enhancement of a human CD8 T cell response to a peptide pool by increasing concentrations of the immune checkpoint inhibitor pembrolizumab.
Assays may be suitable for evaluating modulators of BiTEs, CD3, CD27, CD28, CD40, CD40L, CD70, CD80, CD86, CTLA-4, JAK1, JAK2, JAK3, ICOS, ICOSL, IL-2R, IL-9R, IL-21R, OX40, OX40L, PD-1, PDL-1, TIGIT, TIM-3, STAT1, STAT3, STAT5 and others. |
Further Immunology Assays
B Cells Fibroblasts Haemolysis Testing Human Microglia Macrophages/Monocytes Neutrophils/Granulocytes NK Cells Phagocytosis Assays Regulatory T cells Spheroid Killing Assays Suppression Assays T Cell Exhaustion Assays TIL and dissociated tumour cell assays Tumour Cell Killing Assays |
Celentyx can run plate-based assays for investigating antigen-specific T cell responses (including on purified T cell subsets) quantifying activation markers and proliferation by flow cytometry, or cytokine release by flow cytometry, ELISA, ELISPOT or Luminex, using human primary cells either from healthy volunteers or patients with underlying disease. The example below shows enhancement of a human CD8 T cell response to a peptide pool by increasing concentrations of the immune checkpoint inhibitor pembrolizumab.
Assays may be suitable for evaluating modulators of BiTEs, CD3, CD27, CD28, CD40, CD40L, CD70, CD80, CD86, CTLA-4, JAK1, JAK2, JAK3, ICOS, ICOSL, IL-2R, IL-9R, IL-21R, OX40, OX40L, PD-1, PDL-1, TIGIT, TIM-3, STAT1, STAT3, STAT5 and others.
Assays may be suitable for evaluating modulators of BiTEs, CD3, CD27, CD28, CD40, CD40L, CD70, CD80, CD86, CTLA-4, JAK1, JAK2, JAK3, ICOS, ICOSL, IL-2R, IL-9R, IL-21R, OX40, OX40L, PD-1, PDL-1, TIGIT, TIM-3, STAT1, STAT3, STAT5 and others.
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